반응 #84096

반응 방정식

2-chloro-6-methoxyquinoline

2-(4-(1H-tetrazol-5-yl)phenyl)-6-methoxy-3-methylquinoline

Intermediate 1

2-(4-(1H-tetrazol-5-yl)phenyl)-6-methoxy-3-methylquinoline

4-(methoxycarbonyl) phenylboronic acid

sodium carbonate

→

product

수율 40.9%

methyl 4-(6-methoxyquinolin-2-yl)benzoate

수율 40.9%

용매

1,4-dioxane water

반응 조건

후처리

1. 1
   여과The precipitates were filtered
2. 2
   세척washed with EA (10 mL), acetone (10 mL) and water (10 mL) separately
3. 3
   기타dried

실험 절차

A mixture of 2-chloro-6-methoxyquinoline (Intermediate 1, 200 mg, 1.0 mmol), 4-(methoxycarbonyl) phenylboronic acid (205 mg, 1.1 mmol), Pd(dppf)Cl2 (366 mg, 0.5 mmol) and sodium carbonate (212 mg, 2.0 mmol) in 1,4-dioxane/water (3 mL/0.6 mL) was heated to 120° C. by microwave for 1 h. The precipitates were filtered; washed with EA (10 mL), acetone (10 mL) and water (10 mL) separately; dried to afford product (120 mg, 40.9%).

출처