반응 #84091

반응 방정식

2-chloro-6-methoxyquinoline

5-cyanothiophen-2-ylboronic acid

sodium carbonate

→

5-(6-hydroxyquinolin-2-yl)thiophene-2-carbonitrile

용매

DME

반응 조건

후처리

1. 1
   기타the two step synthesis
2. 2
   기타In step 2, after quenching w/ice water
3. 3
   추출a standard ethyl acetate extraction
4. 4
   기타was preformed followed by purification by prep-TLC (PE: EA=1:1)

실험 절차

Followed the two step synthesis shown in Scheme 1 starting with 2-chloro-6-methoxyquinoline and 5-cyanothiophen-2-ylboronic acid, with minor variations: the base used in step 1 was sodium carbonate and the solvent was DME (dimethoxyethane)/water. In step 2, after quenching w/ice water, a standard ethyl acetate extraction was preformed followed by purification by prep-TLC (PE: EA=1:1).

출처