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2-chloro-4-fluoro-6-methoxyquinoline

Intermediate 7

2-chloro-4-fluoro-6-methoxyquinoline

4-carboxy-2-chlorophenylboronic acid

→

3-chloro-4-(4-fluoro-6-hydroxyquinolin-2-yl)benzoic acid

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실험 절차

Followed Scheme 2, B conditions starting with 2-chloro-4-fluoro-6-methoxyquinoline (Intermediate 7) and 4-carboxy-2-chlorophenylboronic acid. 1H NMR (MeOD 400 MHz): δ 8.20 (d, J=1.2 Hz, 1H), 8.10 (dd, J=8.0, 1.6 Hz, 1H), 8.02 (d, J=9.2, 1.2 Hz, 1H), 7.75 (d, J=8.0 Hz, 1H), 7.52-7.45 (m, 2H), 7.47 (d, J=2.4 Hz, 1H). MS (ESI): m/z 317.9 [M+H]+.

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