반응 #84089

반응 방정식

ethyl 4-(3-chloro-6-methoxyquinolin-2-yl)cyclohex-3-enecarboxylate

→

desired product

수율 26.0%

ethyl 4-(3-chloro-6-methoxyquinolin-2-yl)cyclohexanecarboxylate

수율 26.0%

용매

EtOH

반응 조건

후처리

1. 1
   여과The mixture was filtered off
2. 2
   농축the filtrate was concentrated
3. 3
   기타to give the crude product, which
4. 4
   기타was purified by silica gel column (PE/EtOAc=10/1)

실험 절차

To ethyl 4-(3-chloro-6-methoxyquinolin-2-yl)cyclohex-3-enecarboxylate (900 mg, 2.60 mmol) in EtOH (40 mL) was added Rh(PPh3)3Cl (90.0 mg 0.0900 mmol). The mixture was stirred at 30° C. for 4 days under H2 (15 psi). The mixture was filtered off and the filtrate was concentrated to give the crude product, which was purified by silica gel column (PE/EtOAc=10/1) to give the desired product (234 mg, yield 26%).

출처