반응 #84086

ord-01b08e767e9c47d28248c0e443da1a24

반응 방정식

COC(=O)c1ccc(B(O)O)cc1
4-(methoxycarbonyl)phenylboronic acid
Oc1ccc2nc(Cl)ccc2c1
2-chloroquinolin-6-ol
O=C([O-])[O-].[Na+].[Na+]
Na2CO3
→
COC(=O)c1ccc(-c2ccc3cc(O)ccc3n2)cc1
methyl 4-(6-hydroxyquinolin-2-yl)benzoate

반응물

COC(=O)c1ccc(B(O)O)cc1
4-(methoxycarbonyl)phenylboronic acid
Oc1ccc2nc(Cl)ccc2c1
2-chloroquinolin-6-ol
O=C([O-])[O-].[Na+].[Na+]
Na2CO3

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

Scheme 1, step 1, starting from 4-(methoxycarbonyl)phenylboronic acid and 2-chloroquinolin-6-ol, using Na2CO3 instead of TEA.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US09433618B2uspto-grants-2016_09