반응 #84075

반응 방정식

mixture

4-(4-chloro-3-fluoro-6-methoxyquinolin-2-yl)benzoic acid

→

4-(3-fluoro-6-methoxyquinolin-2-yl)benzoic acid

수율 66.0%

용매

MeOH

반응 조건

후처리

1. 1
   여과The solids were filtered off
2. 2
   농축the filtrate was concentrated
3. 3
   기타to give the product (60 mg, two-step yield 66%)

실험 절차

To a solution of the mixture from Step 1 in absolute MeOH (5 mL) was added Pd/C (10% Pd, 100 mg). The mixture was stirred at 25° C. for 1 hour under H2 atmosphere. The solids were filtered off and the filtrate was concentrated to give the product (60 mg, two-step yield 66%).

출처