반응 #84069

반응 방정식

4-(6-hydroxyquinolin-2-yl)benzonitrile

NH2OH.HCl

→

desired product

수율 78.0%

N-hydroxy-4-(6-hydroxyquinolin-2-yl)benzimidamide

수율 78.0%

용매

EtOH

반응 조건

후처리

1. 1
   농축followed by concentration in vacuo
2. 2
   workup.STIRRINGstirred for 1 hour
3. 3
   여과Filtration
4. 4
   기타drying of the solids

실험 절차

See Scheme 4, route B. 4-(6-hydroxyquinolin-2-yl)benzonitrile (900 mg, 3.68 mmol) was dissolved in 25 mL of EtOH and to it was added NH2OH.HCl (500 mg, 7.36 mmol) and TEA (1.5 mL). The mixture was stirred at 80° C. for 2 hours followed by concentration in vacuo. The crude solids were then suspended in 25 mL of H2O and stirred for 1 hour. Filtration and drying of the solids yielded desired product (800 mg, 78% yield).

출처