반응 #84066

반응 방정식

4-cyanophenylboronic acid

2,4-dichloro-6-methoxyquinoline

→

desired product

4-(4-chloro-6-methoxyquinolin-2-yl)benzonitrile

용매

DMF

반응 조건

후처리

1. 1
   온도to cool
2. 2
   기타The resulting solid was isolated by filtration
3. 3
   세척washed with water
4. 4
   기타dried
5. 5
   기타followed by recrystallization from methanol

실험 절차

Followed Scheme 2, Step 1 starting from 4-cyanophenylboronic acid and 2,4-dichloro-6-methoxyquinoline, where the solvent used was DMF, and the catalyst used was Pd(PPh3)4. The mixture was heated to 100° C. for 3 h, allowed to cool, and then poured into ice water. The resulting solid was isolated by filtration, washed with water, and dried followed by recrystallization from methanol to give the desired product.

출처