반응 #84053

반응 방정식

6-aminoquinoline

pentafluorophenyl (1-azabicyclo[2.2.2]oct-3-yl)acetate hydrochloride

DMF

hydrochloric acid

carbonate

→

title compound

2-(1-Azabicyclo[2.2.2]oct-3-yl)-N-(7-quinolinyl)acetamide hydrochloride

용매

acetonitrile

반응 조건

후처리

1. 1
   workup.WAITAfter 1 h
2. 2
   여과the polystyrene resin is filtered off
3. 3
   세척washed with THF
4. 4
   농축The combined filtrates are concentrated in vacuo
5. 5
   기타the crude product is purified by preparative HPLC
6. 6
   기타The hydrochloride is prepared
7. 7
   workup.ADDITIONby mixing the product
8. 8
   농축concentrating again
9. 9
   기타Drying under high vacuum

실험 절차

90.3 mg (0.24 mmol) of pentafluorophenyl (1-azabicyclo[2.2.2]oct-3-yl)acetate hydrochloride are dissolved in 1 ml of DMF, mixed with 51.6 mg (0.36 mmol) of 6-aminoquinoline and stirred at room temperature overnight. 1 g of MP-carbonate (polymer-bound carbonate, capacity: 2.5-3.5 mmol/g; from Argonaut Technologies, USA) is added. After 1 h, the polystyrene resin is filtered off and washed with THF. The combined filtrates are concentrated in vacuo, and the crude product is purified by preparative HPLC. The hydrochloride is prepared by mixing the product with a mixture of 1 M hydrochloric acid and acetonitrile and concentrating again. Drying under high vacuum results in 44 mg (50.2% of theory) of the title compound.

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