반응 #84049

반응 방정식

methyl 6-bromo-1-benzothiophene-2-carboxylate

potassium hydroxide

→

desired product

6-Bromo-1-benzothiophene-2-carboxylic acid

용매

THF

반응 조건

후처리

1. 1
   기타The solvent is removed in vacuo
2. 2
   여과The resulting precipitate is filtered off with suction
3. 3
   세척washed with water
4. 4
   기타dried in vacuo at 50° C

실험 절차

A solution of 4.0 g (14.8 mmol) of methyl 6-bromo-1-benzothiophene-2-carboxylate in 40 ml of a 1:1 mixture of THF and 2 N potassium hydroxide solution is stirred at room temperature for 2 h. The solvent is removed in vacuo, and the residue is acidified with concentrated hydrochloric acid. The resulting precipitate is filtered off with suction, washed with water and dried in vacuo at 50° C. 3.55 g (93.5% of theory) of the desired product are obtained.

출처