반응 #84048
ord-0186fe48a824439e807128658024c08c
반응 방정식
quinuclidin-3-one hydrochloride
sodium methoxide
→
title compound
Quinuclidin-3-one
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1여과The resulting precipitate is filtered off with suction
- 2농축the filtrate is concentrated in vacuo
- 3기타The residue is partitioned between chloroform and water
- 4추출extracted with chloroform
- 5건조The combined organic phases are dried over sodium sulfate
- 6농축concentrated in vacuo
실험 절차
100 g (0.62 mol) of quinuclidin-3-one hydrochloride are suspended in 2 l of methanol. At 0° C., a solution of 33.4 g (0.62 mol) of sodium methoxide in 250 ml of methanol is slowly added dropwise. The mixture is stirred at room temperature for 16 h. The resulting precipitate is filtered off with suction, and the filtrate is concentrated in vacuo. The residue is partitioned between chloroform and water and extracted with chloroform. The combined organic phases are dried over sodium sulfate and concentrated in vacuo. 58.8 g (75.9% of theory) of the title compound are obtained.