반응 #84047

반응 방정식

barbituric acid

3,5-dibromo-2-hydroxybenzaldehyde

→

product 1a

수율 84.6%

5-(3,5-dibromo-2-hydroxybenzylidene) perhydropyrimidine-2,4,6-trione

수율 84.6%

용매

acetic acid

반응 조건

후처리

1. 1
   온도while heating
2. 2
   기타the resulting reaction mixture
3. 3
   여과The produced crystal product was filtered
4. 4
   세척washed with cold acetic acid
5. 5
   세척washed with ether
6. 6
   기타air-dried

실험 절차

0.01 mol (1.28 g) of barbituric acid (5a) were dissolved in 25 ml of glacial acetic acid while heating. Then 0.011 mol (3.08 g) of 3,5-dibromo-2-hydroxybenzaldehyde (6a) were added to the obtained solution while stirring and the resulting reaction mixture was left at room temperature during 36 hours. The produced crystal product was filtered, washed with cold acetic acid, then washed with ether and air-dried. Thereby 3.3 g of product 1a were obtained in the form of yellow needle crystals with melting temperature of 255-260° C. (with decomposition). Output amounted to 77% of the theoretical value.

출처