반응 #84046

반응 방정식

Fmoc-Phe-Gly-NH—(CH2)6NH-Boc

trifluoroacetic acid

→

Fmoc-Phe-Gly-NH(CH2)6—NH2.TFA

용매

CH2Cl2

반응 조건

후처리

1. 1
   기타The solvents were removed under reduced pressure
2. 2
   기타the residue dried at high vacuum

실험 절차

Fmoc-Phe-Gly-NH—(CH2)6NH-Boc (0.7 g) was dissolved in CH2Cl2 (4 mL) at 0° C. under N2 and then trifluoroacetic acid (TFA) (4 mL) was added. The reaction mixture was allowed to warm to RT and stirred for 2 hours under N2. The solvents were removed under reduced pressure and the residue dried at high vacuum to provide 0.71 g of Fmoc-Phe-Gly-NH(CH2)6—NH2.TFA. This crude material was used to prepare without further purification.

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