반응 #83994

반응 방정식

Propargylamine

methyl trifluoroacetate

→

trifluoroacetamide

수율 91.4%

N-PROPARGYLTRIFLUOROACETAMIDE

수율 91.4%

반응 조건

후처리

1. 1
   workup.DISTILLATIONdistillation through a 15 cm Vigreaux column

실험 절차

Propargylamine (24.79 g, 0.450 mole; Aldrich, 99%) was added dropwise over 1 hour to methyl trifluoroacetate (69.19 g, 0.540 mole, 1.2 eq, Aldrich) at 0°. After stirring an additional hour at 0°, distillation through a 15 cm Vigreaux column afforded 62.12 g (91%) of trifluoroacetamide 18 as a colorless liquid (bp 68.5°-69.5° at 11 torr). This material was homogeneous by NMR and GC and was used interchangeably with spectroscopically-identical material prepared by acylating propargylamine with trifluoroacetic acid anhydride.

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