반응 #83828

반응 방정식

2-chlorocyclohexanone

potassium carbonate

2-chlorocyclohexanone

2-isopropylthio-3-hydroxypyridine

potassium carbonate

acetic acid

2-chlorocyclohexanone

potassium carbonate

→

ketone

수율 72.7%

2-isopropylthio-3-(cyclohexanon-2-yloxy)-pyridine

수율 72.7%

용매

ethyl acetate

dimethylformamide

반응 조건

후처리

1. 1
   workup.STIRRINGthe suspension is stirred for a further 3.5 hours at 45°-50° C
2. 2
   기타The resulting reaction solution
3. 3
   workup.ADDITIONis poured onto a mixture
4. 4
   세척washed three times with 300 ml of ethyl acetate and 100 ml of saturated sodium chloride solution each time
5. 5
   건조dried over sodium sulfate
6. 6
   농축concentrated by evaporation
7. 7
   기타The residue is triturated with petroleum ether
8. 8
   여과filtered

실험 절차

7.29 g of 2-chlorocyclohexanone are added at room temperature to a mixture of 8.4 g of 2-isopropylthio-3-hydroxypyridine and 7.6 g of potassium carbonate in 120 ml of dimethylformamide, and the mixture is stirred for one hour at 45°-50° C. After the addition of 1.46 g of 2-chlorocyclohexanone and 1.52 g of potassium carbonate and after 2 hours of a further analogous addition of 0.73 g of 2-chlorocyclohexanone and 0.76 g of potassium carbonate, the suspension is stirred for a further 3.5 hours at 45°-50° C. The resulting reaction solution is poured onto a mixture consisting of 200 ml of ice-water, 50 ml of 2N acetic acid and 100 ml of ethyl acetate, washed three times with 300 ml of ethyl acetate and 100 ml of saturated sodium chloride solution each time, dried over sodium sulfate and concentrated by evaporation. The residue is triturated with petroleum ether and filtered. 9.57 g of the desired ketone having a melting point of 106°-110° C. are obtained.

출처