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2-hydroxymethyl-1H-imidazo[4,5-b]pyridine

sodium hydride

methyl iodide

→

title compound

2-Hydroxymethyl-1-methyl-1H-imidazo[4,5-b]pyridine

용매

dimethylformamide

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후처리

1. 1
   기타A procedure similar to that described in Preparation 15

실험 절차

A procedure similar to that described in Preparation 15 was repeated, except that 45 g of 2-hydroxymethyl-1H-imidazo[4,5-b]pyridine, 13.17 g of sodium hydride (as a 55% by weight dispersion in mineral oil), 20.7 ml of methyl iodide and 1.43 liter of dimethylformamide were used, to give the title compound as a crude product. This crude product was purified by column chromatography through silica gel, using a gradient elution method, with mixtures of ethyl acetate and methanol in ratios ranging from 1:0 to 1:1 by volume as the eluent, to give 3.24 g of the title compound, melting at 130°-132° C.

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