반응 #837224

반응 방정식

(R)-2-(4-hydroxy-phenoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

5-chloro-6-chloromethyl-benzo[1,3]dioxole

→

title product

수율 40.0%

(R)-2-[4-(6-Chloro-benzo[1,3]dioxol-5-ylmethoxy)phenoxymethyl]pyrrolidine-1-carboxylic acid tert-butyl ester

수율 40.0%

반응 조건

실험 절차

Followed the same procedure as that of step 2 in Example 91 with the use of (R)-2-(4-hydroxy-phenoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (150 mg, 0.5 mmol) and 5-chloro-6-chloromethyl-benzo[1,3]dioxole (125 mg, 0.6 mmol) to afford the title product (80 mg, 40% yield).

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