반응 #837211

반응 방정식

Product

(S)-2-(4-Benzyloxy-phenoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

→

title product

수율 70.2%

(S)-2-(4-Hydroxy-phenoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

수율 70.2%

용매

EtOH THF

반응 조건

후처리

1. 1
   기타Reaction Mixture
2. 2
   여과was filtered through Celite
3. 3
   농축concentrated under reduced pressure
4. 4
   기타The crude mixture was purified by silica gel flash chromatography (20% EtOAc/Hexane)

실험 절차

Product from step 1 (1.2 g, 3.13 mmol) in EtOH/THF (10 mL/25 mL) was treated with 10% Pd on carbon (1.0 g) over period of 16 h at rt under H2 balloon. Reaction Mixture was filtered through Celite and concentrated under reduced pressure. The crude mixture was purified by silica gel flash chromatography (20% EtOAc/Hexane) to obtain the title product (645 mg, 70%).

출처