반응 #837119

반응 방정식

product

(R)-2-[4-(biphenyl-4-yloxy)-phenoxymethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

HCl

→

title product

수율 62.0%

(R)-2-[4-(Biphenyl-4-yloxy)-phenoxymethyl]-pyrrolidine hydrochloride

수율 62.0%

용매

dioxane

반응 조건

실험 절차

Following the general procedure for Example 11 (step 4), the product from step 3 (0.2 g, 0.45 mmol) was treated with 4M HCl in dioxane (5 mL) to afford the title product (0.11 g, 62%) as a white solid; 1H NMR (400 MHz, DMSO-d6) 1.75 (m, 1H), 1.88-2.02 (m, 2H), 2.12 (m 1H), 3.23 (m, 2H), 3.91 (m, 1H), 4.14 (m 1H), 4.26 (dd, J1=3.8 Hz, J2=10.4 Hz, 1H), 7.00 (d, J=8.8 Hz, 2H), 7.04-7.11 (m, 4H), 7.34 (m, 1H), 7.45 (m, 2H), 7.61-7.66 (m, 4H); MS (m/z) 346.7 (M+1); LC (98.9%); Elemental Analysis (Calc): C, 72.34; H, 6.33; N, 3.67. (Found): C, 71.72; H, 6.29; N, 3.66.

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