반응 #83702

반응 방정식

(3aRS,4RS,7SR,7aRS)-2-benzyl-7-(hydroxymethyl)-4-(2-methoxyphenyl)-7-methyl-4-perhydroisoindolol

→

(3aRS,4RS,7SR,7aRS)-7-(hydroxymethyl)-4-(2-methoxyphenyl)-7-methyl-4-perhydroisoindolol

수율 56.1%

용매

ethanol

반응 조건

후처리

1. 1
   기타After sparging with hydrogen for two hours
2. 2
   온도the reaction mixture is cooled to room temperature
3. 3
   기타flushed with a stream of nitrogen
4. 4
   여과filtered
5. 5
   농축concentrated under reduced pressure (2.7 kPa)

실험 절차

A mixture of 3.5 g of (3aRS,4RS,7SR,7aRS)-2-benzyl-7-(hydroxymethyl)-4-(2-methoxyphenyl)-7-methyl-4-perhydroisoindolol, 2.0 g of 20% palladium hydroxide on charcoal and 75 cm3 of ethanol is heated to 50° C. After sparging with hydrogen for two hours, the reaction mixture is cooled to room temperature and flushed with a stream of nitrogen, filtered and concentrated under reduced pressure (2.7 kPa). 1.5 g of (3aRS,4RS,7SR,7aRS)-7-(hydroxymethyl)-4-(2-methoxyphenyl)-7-methyl-4-perhydroisoindolol are obtained in the form Of a white solid.

출처