반응 #83676

반응 방정식

(3aRS,4RS,7aSR)-2-benzyl-4-(2-methoxyphenyl)-4-perhydroisoindolol

→

(3aRS,4RS,7aSR)-4-(2-methoxyphenyl)-4-perhydroisoindolol

수율 48.8%

용매

ethanol

반응 조건

후처리

1. 1
   workup.STIRRINGhydrogenated, with stirring, at a temperature of 60° C. and at atmospheric pressure
2. 2
   기타After reaction for 6 hours the reaction mixture
3. 3
   여과is filtered
4. 4
   농축concentrated to dryness under reduced pressure (2.7 kPa)

실험 절차

A mixture of 16 g of (3aRS,4RS,7aSR)-2-benzyl-4-(2-methoxyphenyl)-4-perhydroisoindolol and 200 cm3 of anhydrous ethanol is heated at 60° C. with stirring; 2 g of 20% palladium hydroxide on charcoal are added and the reaction mixture is then hydrogenated, with stirring, at a temperature of 60° C. and at atmospheric pressure. After reaction for 6 hours the reaction mixture is filtered and then concentrated to dryness under reduced pressure (2.7 kPa). 5.72 g of (3aRS,4RS,7aSR)-4-(2-methoxyphenyl)-4-perhydroisoindolol are obtained in the form of a cream-coloured foam.

출처