반응 #83662

반응 방정식

3-hydroxy-6-methoxy-2,4,5-trimethylbenzyl chloride

2-(4-Acetylamino-2-isopropyl-5-methylphenoxy)ethylamine

triethylamine

→

title compound

수율 5.8%

N-(3-hydroxy-6-methoxy-2,4,5-trimethylbenzyl)-2-(4-acetylamino-2-isopropyl-5-methylphenoxy)ethylamine

수율 5.8%

용매

N,N-dimethylformamide

N,N-dimethylformamide

반응 조건

후처리

1. 1
   workup.ADDITIONwas added dropwise
2. 2
   workup.STIRRINGThe mixture was stirred for 5 hours
3. 3
   기타After the completion of the reaction
4. 4
   workup.DISTILLATIONthe solvent was distilled off
5. 5
   workup.ADDITIONwater and ethyl acetate were added
6. 6
   workup.STIRRINGThe mixture was stirred
7. 7
   여과an insoluble matter was collected by filtration
8. 8
   기타The obtained solid was recrystallized from ethyl acetate

실험 절차

2-(4-Acetylamino-2-isopropyl-5-methylphenoxy)ethylamine (1.0 g) and triethylamine (0.50 g) were dissolved in N,N-dimethylformamide (20 ml), and 3-hydroxy-6-methoxy-2,4,5-trimethylbenzyl chloride (0.86 g) dissolved in N,N-dimethylformamide (10 ml) was added dropwise while stirring the mixture at room temperature. The mixture was stirred for 5 hours. After the completion of the reaction, the solvent was distilled off, and water and ethyl acetate were added. The mixture was stirred and an insoluble matter was collected by filtration. The obtained solid was recrystallized from ethyl acetate to give 100 mg of the title compound.

출처