반응 #83650

반응 방정식

3,4-dihydro-N-(phenylmethyl)-2H-1-benzopyran-2-methanamine

4-bromobutanenitrile

N,N-dimethylformamide

→

(±)-4-[[(3,4-dihydro-2H-1-benzopyran-2-yl)methyl](phenylmethyl) amino]-butanenitrile

수율 69.6%

용매

N,N-diethylethanamine

반응 조건

후처리

1. 1
   기타The reaction mixture was evaporated
2. 2
   기타the residue was partitioned between 1,1'-oxybisethane and water
3. 3
   기타The organic layer was separated
4. 4
   기타dried
5. 5
   여과filtered
6. 6
   기타evaporated

실험 절차

A mixture of 12.5 g of 3,4-dihydro-N-(phenylmethyl)-2H-1-benzopyran-2-methanamine, 9 g of 4-bromobutanenitrile, 200 ml of N,N-dimethylformamide and 10 ml of N,N-diethylethanamine was stirred for 72 hour at room temperature. The reaction mixture was evaporated and the residue was partitioned between 1,1'-oxybisethane and water. The organic layer was separated, dried, filtered and evaporated, yielding 11 g (68.7%) of (±)-4-[[(3,4-dihydro-2H-1-benzopyran-2-yl)methyl](phenylmethyl) amino]-butanenitrile (interm. 53).

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