반응 #836426

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4-(Benzyloxy)-7-((1R)-2-{benzyl[6-(4-phenylbutoxy)hexyl]amino}-1-hydroxyethyl)-1,3-benzothiazol-2(3H)-one

formic acid

→

title compound

4-Hydroxy-7-((1R)-1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)-1,3-benzothiazol-2(3H)-one formate

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후처리

1. 1
   기타the catalyst was removed by filtration through celite
2. 2
   기타the filtrate evaporated in vacuo
3. 3
   기타The residue was purified on mass

실험 절차

4-(Benzyloxy)-7-((1R)-2-{benzyl[6-(4-phenylbutoxy)hexyl]amino}-1-hydroxyethyl)-1,3-benzothiazol-2(3H)-one (7.4 mg) was dissolved in 98% formic acid (0.5 ml)and palladium black catalyst (4 mg) added. After stirring for 8 h, the catalyst was removed by filtration through celite and the filtrate evaporated in vacuo. The residue was purified on mass directed autoprep, to give the title compound (0.51 mg). LCMS RT=2.95 min. ES+ve 459 (M+H)+

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