반응 #836423

반응 방정식

7-acetyl-4-(benzyloxy)-1,3-benzothiazol-2(3H)-one

phenyltrimethylammonium tribromide

→

title compound

수율 93.3%

4-(Benzyloxy)-7-(bromoacetyl)-1,3-benzothiazol-2(3H)-one

수율 93.3%

용매

water

THF

반응 조건

후처리

1. 1
   추출extracted with ethyl acetate
2. 2
   건조dried (MgSO4)
3. 3
   여과filtered
4. 4
   기타evaporated in vacuo
5. 5
   기타The residue was purified on a 5 g silica SPE cartridge
6. 6
   세척eluting

실험 절차

To a solution of 7-acetyl-4-(benzyloxy)-1,3-benzothiazol-2(3H)-one (68 mg) in dry THF (3 ml) under nitrogen, was added phenyltrimethylammonium tribromide (90 mg) and the mixture heated at 80° C. under nitrogen for 2 h. The mixture was diluted with water, extracted with ethyl acetate, dried (MgSO4), filtered and evaporated in vacuo. The residue was purified on a 5 g silica SPE cartridge, eluting with stepped gradient of 10% to 100% ethyl acetate-cyclohexane mixtures, to give the title compound (49 mg).

출처