반응 #83630

반응 방정식

(2aS,4R)-1-benzoyl-6-iodo-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole

potassium hydroxide

→

debenzoylated product

수율 96.7%

(2aS,4R)-6-iodo-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole

수율 96.7%

용매

water

반응 조건

후처리

1. 1
   온도was refluxed under nitrogen for 5 hours
2. 2
   추출the product was extracted into methylene chloride
3. 3
   기타After drying the
4. 4
   추출extract over sodium sulfate the solvent
5. 5
   기타was evaporated

실험 절차

A mixture of 100 g (0.21 mol) of (2aS,4R)-1-benzoyl-6-iodo-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole and 1 liter of 1M ethanolic potassium hydroxide was refluxed under nitrogen for 5 hours. The cooled mixture was diluted with two volumes of water, and the product was extracted into methylene chloride. After drying the extract over sodium sulfate the solvent was evaporated leaving 78 g of the debenzoylated product as a light brown oil.

출처