반응 #83626

반응 방정식

(-)(2aR,4S)-6-(5-oxazolyl)-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole

→

title compound

수율 34.4%

(-)(4R)-6-(5-oxazolyl)-4-(di-n-propylamino)-1,3,4,5-tetrahvdrobenz[cd]indole

수율 34.4%

용매

methylene chloride

반응 조건

후처리

1. 1
   기타The oxidant was removed by filtration through celite
2. 2
   기타The crude product obtained
3. 3
   여과after filtering
4. 4
   기타removing the solvent
5. 5
   기타was purified by flash chromatography

실험 절차

A mixture of (-)(2aR,4S)-6-(5-oxazolyl)-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole (300 mg, 0.9 mmol) and 0.5 g of MnO2 in 50 ml of methylene chloride was stirred at room temperature for 16 hours. The oxidant was removed by filtration through celite. The crude product obtained after filtering and removing the solvent was purified by flash chromatography, using ethyl acetate as eluent, to provide 100 mg of title compound. Recrystallization from hexane gave 60 mg of pure title compound.

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