반응 #83623

반응 방정식

(+)(2aS,4R)-6-(3-isoxazolyl)-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole

→

isoxazole indole

수율 30.9%

(+)(4S)-6-(3-isoxazolyl)-4-(di-n-propylamino)-1,3,4,5-tetrahydrobenz[cd]indole

수율 30.9%

용매

CH2Cl2

반응 조건

후처리

1. 1
   기타was sonicated at 50-55 KHz for 2 hr
2. 2
   온도The reaction mixture warmed
3. 3
   온도to reflux during the time period
4. 4
   여과The reaction mixture was filtered through a celite pad
5. 5
   농축the filtrate was concentrated to dryness in vacuo
6. 6
   기타The residue was chromatographed (flash column, silica gel, ethyl acetate)

실험 절차

A mixture of (+)(2aS,4R)-6-(3-isoxazolyl)-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole (180 mg, 0.5 mmol) and 1 g of MnO2 in 40 mL of CH2Cl2 was sonicated at 50-55 KHz for 2 hr. The reaction mixture warmed to reflux during the time period. The reaction mixture was filtered through a celite pad and the filtrate was concentrated to dryness in vacuo. The residue was chromatographed (flash column, silica gel, ethyl acetate) to provide 50 mg of the isoxazole indole product as an oil. MS (FD) 323

출처