반응 #83615

반응 방정식

(+)(2aS,4R)-6-acetyl-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole

triethylamine

2,2,2-trichloroethylchloroformate

→

1-carbamylindoline

용매

CH2Cl2

CH2Cl2

반응 조건

후처리

1. 1
   추출extracted with water and 1N HCl
2. 2
   세척The organic solution was washed with a saturated NaHCO3 solution
3. 3
   건조a saturated brine solution, dried over MgSO4
4. 4
   농축concentrated to dryness in vacuo

실험 절차

To a solution of (+)(2aS,4R)-6-acetyl-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole (1.7 g, 5.7 mmol) and triethylamine (0.8 ml, 6 mmol) in 90 ml CH2Cl2 was added dropwise a solution of 2,2,2-trichloroethylchloroformate (1.3 g, 6 mmol) in 10 ml CH2Cl2. The reaction mixture was stirred at room temperature for one hour and then extracted with water and 1N HCl. The organic solution was washed with a saturated NaHCO3 solution, a saturated brine solution, dried over MgSO4 and then concentrated to dryness in vacuo to give 2.5 g of the 1-carbamylindoline.

출처