반응 #83589

반응 방정식

5-[3-hydroxy-2-(2-methoxycarbonylethyl)-6-pyridyl]-4-pentynoic acid methyl ester

→

5-[3-hydroxy-2-(2-methoxycarbonylethyl)-6-pyridyl]-pentanoic acid methyl ester

수율 65.6%

용매

methanol

반응 조건

후처리

1. 1
   기타The crude product is chromatographed on silica gel with hexane/0-50% ethyl acetate

실험 절차

Under the conditions of example 14 A, a solution of 1 g of 5-[3-hydroxy-2-(2-methoxycarbonylethyl)-6-pyridyl]-4-pentynoic acid methyl ester in 10 ml of methanol is hydrogenated in the presence of 100 mg of 10% palladium catalyst on activated carbon and worked up. The crude product is chromatographed on silica gel with hexane/0-50% ethyl acetate. 665 mg of 5-[3-hydroxy-2-(2-methoxycarbonylethyl)-6-pyridyl]-pentanoic acid methyl ester of melting point 92°-95° C. is obtained.

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