반응 #83588

반응 방정식

3-(3-hydroxy-6-iodo-2-pyridyl)-propionic acid methyl ester

4-pentynoic acid methyl ester

→

5-[3-hydroxy-2-(2-methoxycarbonylethyl)-6-pyridyl]-4-pentynoic acid methyl ester

수율 84.3%

반응 조건

후처리

1. 1
   기타the crude product is chromatographed on silica gel with hexane/0-30% ethyl acetate

실험 절차

Under the conditions of example 5A, 2 g of 3-(3-hydroxy-6-iodo-2-pyridyl)-propionic acid methyl ester is reacted with 0.8 g of 4-pentynoic acid methyl ester, worked up, and the crude product is chromatographed on silica gel with hexane/0-30% ethyl acetate. 1.6 g of 5-[3-hydroxy-2-(2-methoxycarbonylethyl)-6-pyridyl]-4-pentynoic acid methyl ester of melting point 119°-121° C. is obtained.

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