반응 #8358

반응 방정식

sulfuryl chloride

dichloromethane

7-bromo-4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-quinoline

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title compound

7-Bromo-4-(4-chloro-2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-quinoline

용매

pyridine

반응 조건

후처리

1. 1
   농축concentrated in vacuo
2. 2
   기타The residue is partitioned between chloroform and saturated sodium chloride
3. 3
   건조The organic layer is dried (sodium sulfate)
4. 4
   여과filtered
5. 5
   농축concentrated in vacuo
6. 6
   기타the residue chromatographed on SiO2 (dichloromethane to 20% methanol in dichloromethane)

실험 절차

A solution of 1 M sulfuryl chloride in dichloromethane (20 mL, 20 mmol) is added to a solution of 7-bromo-4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-quinoline (2.2 g, 5.62 mmol) in dry pyridine (50 mL). The mixture is stirred for 18 h and concentrated in vacuo. The residue is partitioned between chloroform and saturated sodium chloride. The organic layer is dried (sodium sulfate), filtered, concentrated in vacuo, and the residue chromatographed on SiO2 (dichloromethane to 20% methanol in dichloromethane) to yield the title compound as a red solid, 1.8 g (75%).

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