반응 #83573

반응 방정식

4-bromophenylacetic acid

methanol

→

4-bromophenylacetic acid methyl ester

반응 조건

후처리

1. 1
   세척the filter residue is washed with dichloromethane
2. 2
   농축the filtrate is concentrated by evaporation
3. 3
   세척washed with 10% sodium bicarbonate solution and saturated common salt solution
4. 4
   기타dried on sodium sulfate
5. 5
   농축concentrated by evaporation

실험 절차

A solution of 100 g of 4-bromophenylacetic acid in 1.5 l of methanol is mixed with 232 g of Amberlyst 15, and the suspension is stirred for 48 hours at room temperature. The reaction mixture is suctioned off on diatomaceous earth, the filter residue is washed with dichloromethane, and the filtrate is concentrated by evaporation. The residue is taken up in ethyl acetate, washed with 10% sodium bicarbonate solution and saturated common salt solution, dried on sodium sulfate and concentrated by evaporation. 106 g of 4-bromophenylacetic acid methyl ester is obtained as oil.

출처