반응 #835694

반응 방정식

6-Bromooxindole

N-Bromosuccinimide

→

title compound

수율 83.0%

5,6-Dibromo-1,3-dihydroindol-2-one

수율 83.0%

용매

acetic acid

반응 조건

후처리

1. 1
   workup.STIRRINGthe yellow reaction mixture was stirred for 3 h at ambient temperature
2. 2
   workup.ADDITIONThe mixture was poured onto ice
3. 3
   여과the resulting precipitate was collected by filtration
4. 4
   기타dried in vacuo

실험 절차

6-Bromooxindole (0.168 g, 0.8 mmol) was dissolved in acetic acid (4 mL) and stirred for 5 min at room temperature. N-Bromosuccinimide (0.14 g, 0.8 mmol) was added and the yellow reaction mixture was stirred for 3 h at ambient temperature. The mixture was poured onto ice and the resulting precipitate was collected by filtration and dried in vacuo to give 0.192 g (83% yield) of the title compound as a white solid: 1H NMR (DMSO-d6, 400 MHz) δ 10.61 (s, 1 H), 7.60 (s, 1 H), 7.14 (s, 1 H), 3.52 (s, 2 H).

출처