반응 #83549

ord-3b7e6ccaafe64f7b8084cf8745a5a28c

반응 방정식

CO
methanol
COC(=O)CCc1nc(C#CC2C=CC(OC)=CC2=C=O)ccc1OCCC(C)CCC=C(C)C
3-{6-[2-(4-methoxy-carbonylphenyl)-ethinyl]-3-[(3RS)-3,7-dimethyl-6-octenyloxy]-2-pyridyl}-propionic acid methyl ester
[Na+].[OH-]
sodium hydroxide
→
CC(C)=CCCC(C)CCOc1ccc(C#Cc2ccc(C(=O)O)cc2)nc1CCC(=O)O
title compound
CC(C)=CCCC(C)CCOc1ccc(C#Cc2ccc(C(=O)O)cc2)nc1CCC(=O)O
3-{6-[2-(4-Carboxyphenyl)-ethinyl]-3-[(3RS)-3,7-dimethyl-6-octenyloxy]-2-pyridyl}-propionic acid

반응물

CO
methanol
COC(=O)CCc1nc(C#CC2C=CC(OC)=CC2=C=O)ccc1OCCC(C)CCC=C(C)C
3-{6-[2-(4-methoxy-carbonylphenyl)-ethinyl]-3-[(3RS)-3,7-dimethyl-6-octenyloxy]-2-pyridyl}-propionic acid methyl ester
—
2n
[Na+].[OH-]
sodium hydroxide

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

Under the conditions of example 3 C, 500 mg of 3-{6-[2-(4-methoxy-carbonylphenyl)-ethinyl]-3-[(3RS)-3,7-dimethyl-6-octenyloxy]-2-pyridyl}-propionic acid methyl ester in 10 ml of methanol is saponified with 7.2 ml of 2n sodium hydroxide solution and worked up. 437 mg of the title compound of melting point 154°-156° C. is obtained.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US05624943uspto-grants-1997_04