반응 #834604

반응 방정식

4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-oxazolepropanol

2-hydroxyindane

tributylphosphine

1,1′-(azodicarbonyl)dipiperidine

→

4-(4-chlorophenyl)-5-[3-(5-indanyloxy)propyl]-2-(2-methyl-1-imidazolyl)oxazole

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   농축After the reaction mixture was concentrated

실험 절차

To a mixture of 4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-oxazolepropanol (318 mg), 2-hydroxyindane (268 mg), tributylphosphine (405 mg) and tetrahydrofuran (10 ml) was added 1,1′-(azodicarbonyl)dipiperidine (400 mg) at room temperature, and the resulting mixture was stirred for 1 hour. After the reaction mixture was concentrated, the residue was subjected to silica gel column chromatography, and 4-(4-chlorophenyl)-5-[3-(5-indanyloxy)propyl]-2-(2-methyl-1-imidazolyl)oxazole was obtained as an oil (418 mg, 96%) from an ethyl acetate-hexane (1:1, v/v)-eluted fraction.

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