반응 #8344

반응 방정식

ethyl acetate

3-ethoxycarbonyl-5-pyridin-2-yl-4-quinolin-4-yl-pyrazole

2-bromoethanol

cesium carbonate

→

title compound

2-Pyridin-2-yl-3-quinolin-4-yl-pyrazolo[5,1-c]morpholin-4-one

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   온도The mixture is cooled to room temperature
2. 2
   세척The organic portion is washed with water
3. 3
   건조dried (sodium sulfate)
4. 4
   여과filtered
5. 5
   농축concentrated in vacuo
6. 6
   기타The residue is chromatographed on SiO2 (ethyl acetate/hexane)

실험 절차

A mixture of 3-ethoxycarbonyl-5-pyridin-2-yl-4-quinolin-4-yl-pyrazole (0.35 g, 1.00 mmol), 2-bromoethanol (0.15 g, 1.12 mmol), and cesium carbonate (0.50 g, 1.5 mmol) in N,N-dimethylformamide (20 mL) is heated at 60° C. for 2 h. The mixture is cooled to room temperature and poured into ethyl acetate (60 mL). The organic portion is washed with water, dried (sodium sulfate), filtered, and concentrated in vacuo. The residue is chromatographed on SiO2 (ethyl acetate/hexane) to yield the title compound, 110 mg (32%).

출처