반응 #834247

반응 방정식

TFA

product

(R)-tert-butyl 6-bromo-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate

→

crude product

(R)-tert-butyl 6-vinyl-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate

용매

DCM

반응 조건

후처리

1. 1
   기타the reaction mixture was evaporated to dryness
2. 2
   workup.ADDITIONNEt3 (1 mL) was added to the residue
3. 3
   기타evaporated again

실험 절차

TFA (0.7 mL, 9.07 mmol) was added dropwise to a solution of the product from step A (620 mg, 2.27 mmol) in DCM (10 mL). After stirring at room temperature for 4 h, the reaction mixture was evaporated to dryness. NEt3 (1 mL) was added to the residue and evaporated again to give the crude product, which was directly used in the next step.

출처