반응 #83424

반응 방정식

water

ethyl 4-aminobenzoate

2-methylbenzoyl chloride

triethylamine

→

ethyl 4-[(2-methylbenzoyl)amino]benzoate

수율 76.5%

용매

dichloromethane

반응 조건

후처리

1. 1
   온도is cooled in an ice bath
2. 2
   workup.ADDITIONAfter the addition
3. 3
   기타the organic layer separated
4. 4
   세척The organic layer is washed with water, 1N HCl, 1M NaHCO3
5. 5
   건조dried over Na2SO4
6. 6
   기타The solvent is removed
7. 7
   여과the solid slurried with ethyl acetate and filtered

실험 절차

A mixture of 43.42 g of ethyl 4-aminobenzoate and 40.8 g of 2-methylbenzoyl chloride in 150 ml of dichloromethane is cooled in an ice bath and 26.56 g of triethylamine is added dropwise. After the addition, the solution is stirred at room temperature overnight. The mixture is poured into water and the organic layer separated. The organic layer is washed with water, 1N HCl, 1M NaHCO3 and dried over Na2SO4. The solvent is removed and the solid slurried with ethyl acetate and filtered to give 57 g of ethyl 4-[(2-methylbenzoyl)amino]benzoate as crystals, m.p. 110°-115° C. A mixture of 50.7 g of the preceding compound in 280 ml of ethyl alcohol and 55 ml of 10N NaOH is refluxed for 5 minutes. The mixture is cooled to room temperature, diluted with 200 ml of water and acidified with concentrated hydrochloric acid (pH 1-2). The mixture is filtered and the solid washed with water and dried to give 51 g of the desired product as white crystals, m.p. 270°-275° C.

출처