반응 #83404

반응 방정식

meta-trifluoromethylphenol

sodium hydride

2-chloro-4-methyl-6-(3-thienylmethyloxy)pyridine

→

4-methyl-2-(3-thienylmethyloxy)-6-(meta-trifluoromethylphenoxy)pyridine

용매

dimethylformamide

반응 조건

후처리

1. 1
   workup.ADDITIONwere successively added

실험 절차

To a solution containing meta-trifluoromethylphenol (1.70 g, 0.0021×5.0 mol) and sodium hydride (0.42 g, (ca.60% in mineral oil), 0.0021×5.0 mol) in dimethylformamide, 2-chloro-4-methyl-6-(3-thienylmethyloxy)pyridine (0.5 g, 0.0021 mol) and CuI (0.20 g, 0.0021×0.5 mol) were successively added and the resultant solution was refluxed for about 5 hours.

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