반응 #83372

반응 방정식

2-Chloroquinoline

4-nitrothiophenol

potassium carbonate

→

2-(4-nitrophenylthio)quinoline

수율 77.0%

용매

ethanol

반응 조건

후처리

1. 1
   여과The mixture was filtered
2. 2
   세척the solid washed with ethanol
3. 3
   workup.DISSOLUTIONThe solid was dissolved with ethyl acetate
4. 4
   세척washed with water
5. 5
   건조dried over sodium sulfate
6. 6
   농축concentrated

실험 절차

2-Chloroquinoline (0.12 moles, 20.0 g), 4-nitrothiophenol (0.13 moles, 20.8 g), and potassium carbonate (0.13 moles, 18.5 g) were dissolved in 800 ml ethanol and stirred at room temperature for 1.5 hr. The mixture was filtered and the solid washed with ethanol. The solid was dissolved with ethyl acetate, washed with water, dried over sodium sulfate and concentrated to yield 2-(4-nitrophenylthio)quinoline 26.0 g, 77%. Mass Spec (FD) 282. Calculated for C15H10N2O2S: C, 63.82, H 3.57; N, 9.92. Found: C, 63.55, H 3.59; N, 9.71.

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