반응 #833565

반응 방정식

sodium chloride

1-(but-2-ynyl)-2-chloro-6-(quinolin-2-ylmethyl)-5,6-dihydro-1H-imidazo[4,5-d]-pyridazine-4,7-dione

potassium carbonate

bromoacetonitrile

→

1-(but-2-ynyl)-2-chloro-5-cyanomethyl-6-(quinolin-2-ylmethyl)-5,6-dihydro-1H-imidazo[4,5-d]pyridazine-4,7-dione

용매

dimethylformamide

반응 조건

후처리

1. 1
   추출is extracted three times with ethyl acetate
2. 2
   건조the combined organic phases are dried over sodium sulphate
3. 3
   기타the solvent is removed
4. 4
   기타The residue is purified over silica gel (cyclohexane/ethyl acetate 1:1)

실험 절차

0.20 g 1-(but-2-ynyl)-2-chloro-6-(quinolin-2-ylmethyl)-5,6-dihydro-1H-imidazo[4,5-d]-pyridazine-4,7-dione and 0.25 g potassium carbonate are placed in 4 ml of dimethylformamide. Then 53 μl of bromoacetonitrile are added and the mixture is stirred for 2 h at 40° C. After the addition of aqueous saturated sodium chloride solution the mixture is extracted three times with ethyl acetate, the combined organic phases are dried over sodium sulphate, and then the solvent is removed. The residue is purified over silica gel (cyclohexane/ethyl acetate 1:1).

출처