반응 #833564

반응 방정식

methyl 2-chloro-5-[N′-tert-butoxycarbonyl-N-(quinolin-2-ylmethyl)-hydrazinocarbonyl]-1-(but-2-ynyl)-1H-imidazol-4-carboxylate

hydrochloric acid

→

1-(but-2-ynyl)-2-chloro-6-(quinolin-2-ylmethyl)-5,6-dihydro-1H-imidazo[4,5-d]-pyridazine-4,7-dione

용매

ethyl acetate

dioxane

반응 조건

후처리

1. 1
   온도Then the solution is cooled to ambient temperature
2. 2
   기타the precipitate formed
3. 3
   기타is separated off
4. 4
   세척washed with ethyl acetate and diethyl ether
5. 5
   기타dried in the drying cupboard at 50° C.

실험 절차

2.80 g methyl 2-chloro-5-[N′-tert-butoxycarbonyl-N-(quinolin-2-ylmethyl)-hydrazinocarbonyl]-1-(but-2-ynyl)-1H-imidazol-4-carboxylate are dissolved in 50 ml of ethyl acetate. Then 1.5 ml of 4 M hydrochloric acid in dioxane are added, and the solution is stirred for 2 h at 50° C. Then the solution is cooled to ambient temperature, the precipitate formed is separated off, washed with ethyl acetate and diethyl ether and dried in the drying cupboard at 50° C.

출처