반응 #833557

반응 방정식

naphthalene-2-acetic acid

3-(N-methyl-sulfamoyl)-naphthalene-2-acetic acid

p-toluene-sulfonic acid

→

3,4-dihydro-2-methyl-3-oxo-2H-naphtho[2,3-e]-1,2-thiazine 1,1-dioxide

수율 61.1%

용매

xylene

반응 조건

후처리

1. 1
   온도The reaction mixture was cooled
2. 2
   여과filtered
3. 3
   세척washed with water
4. 4
   농축concentrated
5. 5
   기타Recrystallization from ethanol

실험 절차

This naphthalene-2-acetic acid (2.6 g, 9.4 mmol) was 12 hrs refluxed in 100 mL xylene with the addition of 0.2 g p-toluene-sulfonic acid. The reaction mixture was cooled, filtered, washed with water and concentrated. Recrystallization from ethanol gave 1.5 g (61%) 3,4-dihydro-2-methyl-3-oxo-2H-naphtho[2,3-e]-1,2-thiazine 1,1-dioxide (melting point: 126-127° C.).

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