반응 #833541

반응 방정식

16-hydroxyhexadecanoic acid

HBr

→

desired product

수율 99.0%

16-Bromohexadecanoic acid

수율 99.0%

용매

acetic acid

반응 조건

후처리

1. 1
   기타16-Bromohexadecanoic acid was prepared
2. 2
   온도Upon cooling
3. 3
   여과It was filtered out
4. 4
   세척washed with 3×100 ml of cold water
5. 5
   기타Material was purified by recrystallization from n-hexane
6. 6
   여과filtered out
7. 7
   기타dried on high vacuum

실험 절차

16-Bromohexadecanoic acid was prepared by refluxing for 48 hrs 5.0 gr (18.35 mmole) of 16-hydroxyhexadecanoic acid in 24 ml of 1:1 v/v mixture of HBr (48% aqueous solution) and glacial acetic acid. Upon cooling, crude product was solidified inside the reaction vessel. It was filtered out and washed with 3×100 ml of cold water. Material was purified by recrystallization from n-hexane, filtered out and dried on high vacuum. 6.1 gr (99% yield) of the desired product were obtained.

출처