반응 #833518

반응 방정식

DMF

NBS

1b

1,2-di(2-ethylhexyloxy)benzene

NBS

→

4-bromo-1,2-di(2-ethylhexyloxy)benzene

수율 96.0%

용매

water

반응 조건

후처리

1. 1
   세척The organic layer was washed with a saturated LiCl solution and water
2. 2
   건조After drying with MgSO4 the solvent
3. 3
   기타was removed under reduced pressure
4. 4
   workup.DISTILLATIONThe remaining oil was distilled (160° C./0.01 mmHg)

실험 절차

Solid NBS (26.21 g, 0.147 mol) was added to an ice cold CH2Cl2 solution (250 mL) of 1b under N2 in the absence of light. Just enough DMF was added (30 mL) to dissolve the NBS. The reaction mixture was allowed to warm to room temperature and then stirred for 12 h. The mixture was then poured into water. The organic layer was washed with a saturated LiCl solution and water. After drying with MgSO4 the solvent was removed under reduced pressure. The remaining oil was distilled (160° C./0.01 mmHg) to yield 4-bromo-1,2-di(2-ethylhexyloxy)benzene (2b) in 96% yield as a colorless oil.

출처