반응 #83346

반응 방정식

2-Chloro-6-methoxyquinoline

4-aminothiophenol

dimethylaminopyridine

→

2-(4-aminophenylthio)-6-methoxyquinoline

용매

ethanol

반응 조건

후처리

1. 1
   기타condensed
2. 2
   기타purified by HPLC over silica gel
3. 3
   세척eluted with 25-30% ethyl acetate/hexane

실험 절차

2-Chloro-6-methoxyquinoline (52.0 mmoles, 10.0 g), 4-aminothiophenol (52.0 mmoles, 6.5 g) and dimethylaminopyridine (52.0 mmoles, 6.3 g) were stirred for 16 hr in 250 ml ethanol. The reaction was condensed and purified by HPLC over silica gel eluted with 25-30% ethyl acetate/hexane to yield 2-(4-aminophenylthio)-6-methoxyquinoline. 8.5 g, 58% product. Mass spec (FD) 282. Calculated for C16H14N2OS: C, 68.06; H, 5.00, N, 9.92. Found: C, 68.04; H, 4.97; N, 10.02.

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