반응 #83338

반응 방정식

2-Chloroquinoline

4-aminothiophenol

potassium carbonate

→

2-(4-aminophenylthio)quinoline

수율 40.0%

용매

ethanol

반응 조건

후처리

1. 1
   농축The reaction mixture was concentrated
2. 2
   workup.ADDITIONethyl acetate was added
3. 3
   세척the solution washed with water
4. 4
   건조dried over sodium sulfate
5. 5
   농축concentrated
6. 6
   기타The product was purified by HPLC over silica gel
7. 7
   세척eluted with ethyl acetate/hexane

실험 절차

2-Chloroquinoline (0.04 moles, 6.54 g), 4-aminothiophenol (0.04 moles, 5.0 g) and potassium carbonate (0.04 moles, 5.52 g) were stirred at room temperature in 200 ml of ethanol for 18 hr. The reaction mixture was concentrated, ethyl acetate was added and the solution washed with water, dried over sodium sulfate and concentrated. The product was purified by HPLC over silica gel eluted with ethyl acetate/hexane to yield 2-(4-aminophenylthio)quinoline 4.0 g, 40%. Mass Spec (FD) 252. Calculated for C15H12N2S: C, 71.40; H, 4.79, N, 11.10. Found: C, 71.11; H, 4.98 N, 11.20.

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