반응 #8327

반응 방정식

(S)-1-amino-5-benzyloxymethyl-pyrrolidin-2-one

2-(4-fluoro-phenyl)-1-(6-methyl-pyridin-2-yl)-ethanone

→

title compound

(S)-5-Benzyloxymethyl-1-[2-(4-fluoro-phenyl)-1-(6-methyl-pyridin-2-yl)-ethylideneamino]-pyrrolidin-2-one

용매

toluene

반응 조건

후처리

1. 1
   기타equipped with a Dean-Stark apparatus
2. 2
   온도is refluxed for 1 h
3. 3
   농축The mixture is concentrated in vacuo
4. 4
   기타the residue chromatographed on SiO2 (40% ethyl acetate/hexanes)

실험 절차

A mixture of (S)-1-amino-5-benzyloxymethyl-pyrrolidin-2-one (0.5 g, 2.27 mmol) and 2-(4-fluoro-phenyl)-1-(6-methyl-pyridin-2-yl)-ethanone (0.52 g, 2.27 mmol) in toluene (2.5 mL) in a round bottom flask equipped with a Dean-Stark apparatus is refluxed for 1 h. The mixture is concentrated in vacuo and the residue chromatographed on SiO2 (40% ethyl acetate/hexanes) to yield the title compound, 500 mg (52%), as a pale yellow oil.

출처