반응 #83234

반응 방정식

5-amino-3-(4-fluorophenyl)-4-(pyridin-4-yl)pyrazole

4-methyl-3-penten-2-one

→

6,7-dihydro-2-(4-fluorophenyl)-3-(pyridin-4-yl)-5,7,7-trimethylpyrazolo[1,5-a]pyrimidine

반응 조건

후처리

1. 1
   온도was refluxed for 5 hours
2. 2
   온도The reaction mixture was cooled
3. 3
   농축concentrated in vacuo
4. 4
   기타The residue was purified by column chromatography on silica gel
5. 5
   기타the obtained oil was crystallized from a mixture of ethyl acetate and hexane

실험 절차

A mixture of 5-amino-3-(4-fluorophenyl)-4-(pyridin-4-yl)pyrazole (254 mg) and 4-methyl-3-penten-2-one (5 ml) was refluxed for 5 hours. The reaction mixture was cooled and concentrated in vacuo. The residue was purified by column chromatography on silica gel and the obtained oil was crystallized from a mixture of ethyl acetate and hexane to give 6,7-dihydro-2-(4-fluorophenyl)-3-(pyridin-4-yl)-5,7,7-trimethylpyrazolo[1,5-a]pyrimidine (83 mg).

출처